David Orrell is an applied mathematician, with a DPhil from Oxford University on the prediction of nonlinear systems. He has worked in diverse areas including particle accelerator design, weather forecasting, economics, and systems biology. He currently serves on the Scientific Advisory Board of the UK-based company Physiomics, and the editorial board of Foresight magazine. He is also the author of several books including The Future of Everything: The Science of Prediction.

Hitesh Mistry holds a PhD in applied mathematics from The University of Manchester and is now a modelling and simulation specialist within the pharmaceutical industry. He has worked in projects from target identification (systems biology) through to clinical development (population PKPD – mixed effects) in a variety of therapeutic areas with particular focus on oncology. His work within AstraZeneca led to awards both in oncology and cardiac safety. At Physiomics he was responsible for leading the Virtual Tumour clinical development. He is currently Senior Research Fellow at The University of Manchester working with Cancer Research UK and the Christie Hospital supporting oncology projects.

Nicola Melillo is a pharmacometrics consultant with a PhD in bioengineering from the University of Pavia. He worked as research associate at The University of Manchester, where he used modelling and simulation techniques to study the effect of hepatic transporters drug-drug interactions and to support clinical study design. He is now modelling and simulation consultant at Systems Forecasting, where he applies population PKPD, PBPK modelling and data analysis techniques in a varaiety of projects in different therapeutic areas, from preclinical to clinical settings.